Key result
Optical monitoring of radiofrequency ablation in ex vivo human myocardium showed that transmural lesions exhibit increased absorption and decreased diffuse reflectance compared to normal tissue.
Why the study?
Does real-time optical monitoring detect transmural radiofrequency ablation lesions in ex vivo human myocardium?
Does real-time optical monitoring detect transmural radiofrequency ablation lesions in ex vivo human myocardium?
Real-time optical monitoring of diffuse reflectance can differentiate transmural radiofrequency ablation lesions from normal tissue and superficial lesions in ex vivo human myocardium.
May enable real-time lesion assessment during ablation; hypothesis-generating from ex vivo data, needs in vivo validation.
Radiofrequency catheter ablation (RFA) therapy has emerged as a leading tool for the treatment of cardiac arrhythmias, including atrial fibrillation. Despite the widespread use, current devices possess considerable limitations in confirming successful lesion formation, in vivo. As a result, many clinical benefits are observed after multiple procedures to address recurrence. In this study, a catheter was designed conducive for real-time tissue optical measurements of the RFA treated zone. We found that RFA treated tissue exhibited a significant change in diffuse reflectance compared to the normal myocardium in ex vivo human samples. An algorithm was developed to invert diffuse reflectance into tissue optical properties. It is observed that transmural lesions exhibit an increased absorption and decreased reflectance as compared to normal and superficial lesions. Results are in agreement with published findings for thermally treated myocardium.
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Singh‐Moon et al. (2015) studied Atrial fibrillation. Optical monitoring of radiofrequency ablation using a custom catheter vs. Normal myocardium and superficial lesions was evaluated on Diffuse reflectance and tissue optical properties. Optical monitoring of radiofrequency ablation in ex vivo human myocardium showed that transmural lesions exhibit increased absorption and decreased diffuse reflectance compared to normal tissue.
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