Why the study?
Does 1,1,1-trichloroethane inhalation affect heart rate via the autonomic nervous system in anesthetized dogs?
Does 1,1,1-trichloroethane inhalation affect heart rate via the autonomic nervous system in anesthetized dogs?
Both tachycardia and bradycardia following acute 1,1,1-trichloroethane inhalation in dogs appear to be mediated by the sympathetic nervous system.
May indicate sympathetic mediation of solvent effects on heart rate in dogs; leaves open human relevance.
The response of heart rate to acute 1,1,1-trichloroethane (1,1,1-TCE) inhalation and its mechanism via the autonomic nervous system were studied in anesthetized dogs in acute inhalation experiments. Concentrations of 1,1,1-TCE in inspired air of 1.32 +/- 0.14% (mean +/- S.E.) increased heart rate, but 2.79 +/- 0.24% decreased heart rate. Opposite reactions of heart rate were observed when blood pressure decreased to 70-80 mm Hg following inhalation. Moreover, both tachycardia from relatively low concentrations and bradycardia from higher concentrations were blocked by pre-administration of adrenergic beta blocker, but were only slightly affected by vagotomy. It is suggested that both tachycardia and bradycardia following 1,1,1-TCE inhalation may be controlled by the sympathetic nervous system.
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Kobayashi et al. (1987) studied this question.
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