What does this research mean for the field?

In dog coronary arteries, low concentrations of tyramine induce relaxation by releasing norepinephrine to stimulate beta-adrenoceptors, while high concentrations induce contraction partly through direct action on alpha-adrenoceptors rather than norepinephrine release. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1982The Japanese Journal of PharmacologyOpen Access

Responses of isolated dog coronary arteries to tyramine.

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Population

Isolated dog coronary arteries (including some from reserpine-pretreated dogs)

Design

Preclinical

Authors

SHShigehiro HayashiTokyo Medical University NTNoboru TodaNational Institute of Advanced Industrial Science and Technology

Discussion

Member takes

Implication

Tyramine biphasic coronary effects in dogs warrant experimental caution; leaves open human vasomotor relevance.

Structured PICO

Population

Isolated dog coronary arteries (including some from reserpine-pretreated dogs)

Intervention

Tyramine at various concentrations (10^-6 to 2x10^-3 M), with or without antagonists (propranolol, sotalol, cocaine, bretylium, phentolamine)

Outcome

Vasomotor responses (relaxation or contraction)surrogate

Tyramine induces concentration-dependent biphasic vasomotor responses in isolated dog coronary arteries, with low concentrations causing beta-adrenoceptor-mediated relaxation and high concentrations causing alpha-adrenoceptor-mediated contraction.

Cite This Study

Hayashi et al. (1982) studied this question.

synapsesocial.com/papers/6a1c837594dbf6307b2fdcf7 https://doi.org/10.1254/jjp.32.47

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Responses of isolated dog coronary arteries to tyramine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Responses of isolated dog coronary arteries to tyramine.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider