What is the clinical evidence from this study?

Study design: Other. Population: Normal, denervated, and reserpine-treated carotid arteries. Intervention: Sympathomimetic amines and nicotine vs. Normal arteries. Primary outcome: Vascular response (vasoconstriction/vasodilatation).

What question did this study set out to answer?

To compare the vascular sensitivity of normal, surgically denervated, and reserpine-treated canine carotid arterial segments to sympathomimetic amines and nicotine.

February 1, 1962British Journal of Pharmacology and ChemotherapyOpen Access

Response of Normal, Denervated, and Reserpine‐treated Arteries to Sympathomimetic Amines and Nicotine in Dogs

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Key result

Denervated and reserpine-treated dog carotid arteries showed increased sensitivity to noradrenaline, while nicotine most frequently produced vasodilatation across all vessel types.

Why the study?

How do normal, denervated, and reserpine-treated dog carotid arteries respond to sympathomimetic amines and nicotine?

Population

Isolated perfused segments of dog carotid arteries (normal, denervated, and reserpine-treated)

Comparison

Sympathomimetic amines and nicotine vs Normal arterial segments

Design

Preclinical

Authors

WMWilliam H. MacmillanUniversity of Vermont DSDurwood J. SmithUniversity of Vermont JJJulius H. JacobsonUniversity of Vermont

Discussion

Member takes

Implication

Warrants caution against clinical extrapolation; extends animal models of denervation supersensitivity and nicotine vasodilatation.

Key Points

To compare the vascular sensitivity of normal, surgically denervated, and reserpine-treated canine carotid arterial segments to sympathomimetic amines and nicotine.
Perfused isolated segments of canine carotid arteries from normal controls, reserpine-treated animals, and vessels denervated by peri-arterial stripping or reversed re-anastomosis.
Measured vasoconstrictive and vasodilatory responses following exposure to noradrenaline, tyramine (with or without catecholamine precursor loading), and nicotine across 130 tests.
Reserpine pretreatment and surgical denervation both produced heightened arterial sensitivity to noradrenaline, directly correlating with lower tissue noradrenaline concentrations.
Tyramine failed to trigger vasoconstriction in denervated segments unless vessels received pretreatment with noradrenaline, dopamine, or dopa.
Nicotine primarily induced vasodilatation of both the main arterial wall and the vasa vasorum in normal, reserpine-treated, and denervated arteries across 130 recordings.

Structured PICO

How do normal, denervated, and reserpine-treated dog carotid arteries respond to sympathomimetic amines and nicotine?

Population

Isolated perfused carotid arterial segments from normal, denervated, and reserpine-treated dogs.

Intervention

Sympathomimetic amines (noradrenaline, tyramine, dopamine, dopa) and nicotine

Comparator

Normal (untreated/non-denervated) arterial segments

Outcome

Vasomotor response (vasoconstriction or vasodilatation) and sensitivitysurrogate

Denervation and reserpine treatment increase arterial sensitivity to noradrenaline and alter responses to tyramine, while nicotine consistently induces vasodilatation in dog carotid arteries.

Cite This Study

Macmillan et al. (1962) studied Normal, denervated, and reserpine-treated carotid arteries. Sympathomimetic amines and nicotine vs. Normal arteries was evaluated on Vascular response (vasoconstriction/vasodilatation). Denervated and reserpine-treated dog carotid arteries showed increased sensitivity to noradrenaline, while nicotine most frequently produced vasodilatation across all vessel types.

synapsesocial.com/papers/6a9339ad143cfaca70133cbc https://doi.org/10.1111/j.1476-5381.1962.tb01148.x

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Response of Normal, Denervated, and Reserpine‐treated Arteries to Sympathomimetic Amines and Nicotine in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Response of Normal, Denervated, and Reserpine‐treated Arteries to Sympathomimetic Amines and Nicotine in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider