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This research aims to understand the pharmacokinetics of verapamil and its disposition in the body.

Physiological disposition of verapamil in man

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This research aims to understand the pharmacokinetics of verapamil and its disposition in the body.
Five volunteer patients received verapamil both intravenously (10 mg) and orally (80 mg).
Plasma concentrations were measured using mass fragmentography, assessing parameters like half-life and clearance.
Urinary and fecal excretion of radioactivity were evaluated over a 5-day period.
Verapamil's half-lives for chi-phase and beta-phase ranged from 18 to 35 minutes and 170 to 440 minutes, respectively.
Bioavailability after oral administration was low at 10 to 22%, demonstrating extensive first-pass metabolism.
Approximately 80% of the administered radioactivity was recovered in urine and feces within 5 days.

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Randomized trial explores the pharmacokinetics of verapamil, indicating extensive first-pass metabolism.

Schomerus et al. (1976) studied this question.

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