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April 1, 1991HeartOpen Access

A critical threshold of exercise capacity in the ventilatory response to exercise in heart failure.

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Why the study?

What is the relationship between exercise capacity (VO2max) and ventilatory response (VE/VCO2) in patients with chronic left heart failure compared to healthy controls?

Population

47 patients with chronic left heart failure (NYHA class II and III) and 1009 healthy controls

Comparison

Progressive exercise testing vs Healthy controls

Design

Cross-sectional

Authors

SDSW DaviesUniversity College HospitalTETM EmeryThe Royal Free HospitalMWMIL WatlingGuilford College

Discussion

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Implication

Reveals a VO2max threshold for abnormal ventilatory response in heart failure; hypothesis-generating for prognostic or therapeutic relevance.

Structured PICO

What is the relationship between exercise capacity (VO2max) and ventilatory response (VE/VCO2) in patients with chronic left heart failure compared to healthy controls?

P
Population
47 patients with chronic left heart failure (NYHA class II and III) and 1009 healthy controls
I
Intervention
Progressive exercise testing
C
Comparator
Healthy controls
O
Outcome
Relation between minute ventilation to minute production of carbon dioxide (VE/VCO2) and peak oxygen consumption (VO2max)surrogate

There is a critical threshold of exercise capacity in heart failure below which ventilatory response to exercise (VE/VCO2) abnormally increases, likely due to ventilation-perfusion mismatch.

Cite This Study

Davies et al. (1991) studied this question.

synapsesocial.com/papers/6a1cd9186552df3dce1dafb5https://doi.org/10.1136/hrt.65.4.179
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventilation and Gas Exchange during Exercise in Severe Chronic Heart Failure1984 · 83 citations
  2. 2THE EFFECT OF EXERCISE ON LUNG DISTENSIBILITY AND RESPIRATORY WORK IN MITRAL STENOSIS1955 · 46 citations
  3. 3Increased exercise ventilation in patients with chronic heart failure: intact ventilatory control despite hemodynamic and pulmonary abnormalities.1988 · 438 citations
  4. 4Difference between end-tidal and arterial PCO2 in exercise1979 · 393 citations