What does this research mean for the field?

In patients with chronic heart disease, left ventricular function improves during exercise up to the anaerobic threshold, after which it deteriorates, making the anaerobic threshold a noninvasive marker for the onset of exercise-induced cardiac dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to assess how exercise affects cardiac function in patients with chronic heart disease.

December 1, 1989Circulation

Detecting abnormalities in left ventricular function during exercise by respiratory measurement.

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Why the study?

Does the anaerobic threshold measured by respiratory gas exchange correlate with the onset of exercise-induced left ventricular dysfunction in patients with chronic heart disease?

Population

23 patients with chronic heart disease

Design

Cross-sectional

Authors

AKAtsushi KoikeOsaka University of Pharmaceutical Sciences HIHiroshi ItohPreventive Cardiology KTK TaniguchiKochi Gakuen College

Discussion

Member takes

Implication

Supports anaerobic threshold as marker of exercise-induced LV dysfunction; hypothesis-generating in cross-sectional data and needs prospective validation.

Key Points

This research aims to assess how exercise affects cardiac function in patients with chronic heart disease.
Evaluated 23 patients with chronic heart disease using a cycle ergometer exercise test.
Monitored left ventricular function through ejection fraction using a computerized detector after intravenous injection of technetium-labeled red blood cells.
Determined anaerobic threshold using noninvasive respiratory gas exchange measurement.
Ejection fraction peaked at anaerobic threshold (46.5 +/- 12.0%) but fell to 37.2 +/- 11.0% at peak exercise.
Stroke volume increased at the anaerobic threshold (65.0 +/- 21.2 ml/beat) but decreased at peak exercise (52.4 +/- 18.7 ml/beat).
Cardiac output slope declined above the anaerobic threshold, indicating decreased left ventricular function.

Structured PICO

Does the anaerobic threshold measured by respiratory gas exchange correlate with the onset of exercise-induced left ventricular dysfunction in patients with chronic heart disease?

Population

23 patients with chronic heart disease

Intervention

Symptom-limited exercise test with a cycle ergometer, continuous monitoring of left ventricular ejection fraction using a computerized cadmium telluride detector and technetium-labeled red blood cells, and noninvasive measurement of respiratory gas exchange

Outcome

Left ventricular function (ejection fraction, stroke volume, cardiac output) in relation to the anaerobic threshold during exercisesurrogate

The anaerobic threshold provides an objective, noninvasive marker for the onset of exercise-induced left ventricular dysfunction in patients with chronic heart disease.

Cite This Study

Koike et al. (1989) studied this question.

synapsesocial.com/papers/6a1cd9186552df3dce1dafb6 https://doi.org/10.1161/01.cir.80.6.1737

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Implication

Supports anaerobic threshold as marker of exercise-induced LV dysfunction; hypothesis-generating in cross-sectional data and needs prospective validation.

Detecting abnormalities in left ventricular function during exercise by respiratory measurement.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Detecting abnormalities in left ventricular function during exercise by respiratory measurement.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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