What question did this study set out to answer?

To investigate sex differences in the risk of heart failure associated with diabetes through a systematic review and meta-analysis.

July 17, 2019DiabetologiaOpen Access

Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals

View Full Paper

Ask AI

Bookmark

Why the study?

Diabetes is associated with heart failure, but whether it confers the same excess risk in women and men is unknown.

Does diabetes increase the risk of heart failure more in women than in men?

Population

12,142,998 individuals from 47 cohorts

Comparison

Sex differences in heart failure risk associated with diabetes

Design

Systematic review and random-effects meta-analysis of population-based cohort studies

Authors

TOToshiaki OhkumaKyushu University YKYuji KomoritaKyushu Dental University SPSanne A. E. PetersPreventive Cardiology

Discussion

Member takes

Implication

Women with diabetes have greater excess HF risk than men; supports sex-specific monitoring but prospective trials needed.

Key Points

To investigate sex differences in the risk of heart failure associated with diabetes through a systematic review and meta-analysis.
Conducted systematic search in PubMed for cohort studies from 1966 to 2018.
Selected studies providing sex-specific relative risks (RRs) for heart failure associated with diabetes, adjusted for age.
Utilized random-effects meta-analyses to compute pooled sex-specific RRs and women-to-men ratio of RRs (RRRs).
Pooled RR for heart failure with type 1 diabetes was 5.15 (95% CI 3.43, 7.74) in women vs. 3.47 (2.57, 4.69) in men.
Pooled RR for type 2 diabetes was 1.95 (1.70, 2.22) in women vs. 1.74 (1.55, 1.95) in men.
The women-to-men RRs showed that the risk is 1.47 times higher for women with type 1 diabetes than men.

Structured PICO

Does diabetes increase the risk of heart failure more in women than in men?

Population

12,142,998 individuals from 47 population-based cohorts, including both women and men, with and without diabetes.

Intervention

Diabetes mellitus (Type 1 and Type 2)

Comparator

Individuals without diabetes

Outcome

Heart failure (fatal or non-fatal)hard clinical

Diabetes confers a significantly greater excess risk of heart failure in women compared to men, for both type 1 and type 2 diabetes.

Limitations

Based on published data with heterogeneity in study design, ascertainment of diabetes, definition of endpoint, and extent of adjustment
Potential unmeasured confounding factors
Lack of information on duration of diabetes, glycemic control, glucose-lowering drugs, or heart failure phenotype
Competing risk of premature death was not adjusted for
Only two studies available for type 1 diabetes

Cite This Study

Ohkuma et al. (2019) studied this question.

synapsesocial.com/papers/6a1cdaf8566b67b7d585febc https://doi.org/10.1007/s00125-019-4926-x

Topics

Heart failure HFrEF treatment Women and heart disease

View Full Paper

Ask AI

Bookmark

Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider