What question did this study set out to answer?

This study aims to evaluate the effectiveness of the Hypotension Prediction Index in preventing intraoperative hypotension during general anesthesia.

September 25, 2023Open Access

Hypotension Prediction Index for Prevention of Intraoperative Hypotension in Patients Undergoing General Anesthesia: A Randomized Controlled Trial

View Full Paper

Ask AI

Bookmark

Why the study?

Intraoperative hypotension is a common side effect of general anaesthesia, prompting evaluation of whether the Hypotension Prediction Index warning system reduces its severity and duration.

Does Hypotension Prediction Index guidance reduce the severity of intraoperative hypotension in adult patients undergoing elective non-cardiac surgery with general anesthesia?

Population

Sixty patients undergoing general anaesthesia surgery at a tertiary referral hospital

Comparison

Hypotension Prediction Index guidance vs standard of care

Design

Randomized controlled trial

Follow-up

30 postoperative days

Authors

CLChih-Jun LaiNational Taiwan University YCYa‐Jung ChengNational Taiwan University YHYin‐Yi HanNational Taiwan University

Discussion

Member takes

Implication

Supports HPI guidance to mitigate intraoperative hypotension; extends RCT evidence for predictive monitoring in non-cardiac surgery.

Key Points

This study aims to evaluate the effectiveness of the Hypotension Prediction Index in preventing intraoperative hypotension during general anesthesia.
Randomized controlled trial with 60 patients assigned to intervention or control groups.
Intervention group received guidance based on Hypotension Prediction Index; control group received standard care.
Primary outcome measured was severity of hypotension defined as mean arterial pressure < 65 mmHg.
Intervention group had a lower median time-weighted average mean arterial pressure < 65mmHg (0.02 vs. 0.37, P < 0.001).
Fewer postoperative gastrointestinal symptoms in the intervention group (6 vs. 14, P = 0.028).
Faster response time from alarm to treatment in the intervention group (42.78s vs. 200.16s, P < 0.001).

Structured PICO

Does Hypotension Prediction Index guidance reduce the severity of intraoperative hypotension in adult patients undergoing elective non-cardiac surgery with general anesthesia?

Population

60 adult patients (20-80 years) undergoing elective non-cardiac surgery with general anesthesia requiring continuous invasive blood pressure monitoring, expected to last >4 hours. Median age 62, 80% men. Excluded: emergency procedures, moderate to severe valvular disease, tidal volume <8 mL/kg, and persistent atrial fibrillation.

Intervention

Hemodynamic management with Hypotension Prediction Index (HPI) guidance (treatment initiated at HPI > 85).

Comparator

Standard of care (treatment initiated at mean arterial pressure < 65 mmHg) with muted/obscured HPI monitor.

Outcome

Severity of hypotension, defined as a time-weighted average mean arterial pressure < 65 mmHg.surrogate

Hypotension Prediction Index guidance significantly reduces the severity of intraoperative hypotension and postoperative gastrointestinal symptoms in patients undergoing non-cardiac surgery with general anesthesia.

Cite This Study

Lai et al. (2023) studied this question.

synapsesocial.com/papers/6a1cde705b2142ad731dcef7 https://doi.org/10.21203/rs.3.rs-3350451/v1

View Full Paper

Ask AI

Bookmark

Hypotension Prediction Index for Prevention of Intraoperative Hypotension in Patients Undergoing General Anesthesia: A Randomized Controlled Trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hypotension Prediction Index for Prevention of Intraoperative Hypotension in Patients Undergoing General Anesthesia: A Randomized Controlled Trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider