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May 5, 2025Journal of Interventional Cardiac ElectrophysiologyOpen Access

Quantitative cardiac magnetic resonance standardized signal intensity comparison in dilated cardiomyopathy vs. cardiac sarcoidosis

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Why the study?

Overlapping late gadolinium enhancement patterns on CMR complicate the differentiation between dilated cardiomyopathy and cardiac sarcoidosis due to lack of specificity.

Does quantitative CMR signal intensity z-score analysis distinguish cardiac sarcoidosis from dilated cardiomyopathy in patients with non-ischemic cardiomyopathy?

Population

22 NICM patients (13 DCM, 9 CS) undergoing CMR before electrophysiology study

Comparison

DCM vs CS

Design

Retrospective study

Authors

TLTing‐Wei Ernie LiaoAlbert Einstein College of MedicineLXLingyu XuUniversity of PennsylvaniaMKMirmilad KhoshknabHospital of the University of Pennsylvania

Discussion

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Implication

May support z-score analysis to differentiate cardiac sarcoidosis from dilated cardiomyopathy on CMR; leaves open prospective validation before clinical adoption.

Structured PICO

Does quantitative CMR signal intensity z-score analysis distinguish cardiac sarcoidosis from dilated cardiomyopathy in patients with non-ischemic cardiomyopathy?

P
Population
22 patients with non-ischemic cardiomyopathy (13 with dilated cardiomyopathy [DCM], 9 with cardiac sarcoidosis [CS]) who underwent cardiac magnetic resonance (CMR) before electrophysiology study.
I
Intervention
Quantitative cardiac magnetic resonance (CMR) standardized signal intensity z-score analysis of late gadolinium enhancement (LGE)
C
Comparator
Comparison between dilated cardiomyopathy (DCM) and cardiac sarcoidosis (CS) groups
O
Outcome
Spatial distribution of LGE intensity (CMR signal intensity z-scores) across myocardial segments and layerssurrogate

Standardized z-score analysis of CMR signal intensities provides a novel, quantitative method to distinguish cardiac sarcoidosis from dilated cardiomyopathy, with cardiac sarcoidosis showing higher intensity in the right ventricular endocardial septum.

Cite This Study

Liao et al. (2025) studied this question.

synapsesocial.com/papers/6a1cf7907f448865515d9948https://doi.org/10.1007/s10840-025-02042-7

Topics

Cardiac MRICardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of late gadolinium enhancement extent, location, and pattern on ventricular tachycardia and major adverse cardiac events in patients with ischemic vs. non-ischemic cardiomyopathy2022 · 21 citations
  2. 2Validating an Idiopathic Dilated Cardiomyopathy Diagnosis Using Cardiovascular Magnetic Resonance: The Dilated Cardiomyopathy Precision Medicine Study2022 · 34 citations
  3. 3Impact of late gadolinium-enhanced cardiac MRI on arrhythmic and mortality outcomes in nonischemic dilated cardiomyopathy: updated systematic review and meta-analysis2023 · 39 citations
  4. 4Prognostic Value of Late Gadolinium Enhancement for the Prediction of Cardiovascular Outcomes in Dilated Cardiomyopathy2020 · 115 citations
  5. 5Myocardial Late Gadolinium Enhancement (LGE) in Cardiac Magnetic Resonance Imaging (CMR)—An Important Risk Marker for Cardiac Disease2024 · 50 citations