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February 1, 2001AJP Heart and Circulatory Physiology97 citations

Estimation of Left Ventricular Operating Stiffness from Doppler Deceleration Time in Humans

Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans

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Why the study?

Can early transmitral deceleration time (E(DT)) accurately estimate left ventricular operating stiffness (K(LV)) in humans?

Population

18 patients undergoing open-heart surgery

Design

Cross-sectional

Authors

MGMario J. GarcíaMFMichael S. FirstenbergNGNeil Greenberg

Discussion

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Overview

Early transmitral deceleration time provides an accurate, noninvasive estimate of left ventricular operating stiffness in adults with cardiac disease, supporting its use in evaluating diastolic function.

Key Points

  • This research aims to establish a quantitative relationship between early Doppler deceleration time and left ventricular operating stiffness in humans.
  • Studied 18 patients undergoing open-heart surgery under varying hemodynamic conditions.
  • Utilized transesophageal echocardiography to measure volumes and Doppler flows, along with LA and LV pressures.
  • Calculated K(LV) using established equations relating E(DT) to diastolic pressures and volumes.
  • E(DT) averaged 180 +/- 39 ms and was inversely related to LV end-diastolic pressures (r = -0.56, P = 0.004).
  • The strongest association of E(DT) was with K(LV) (r = -0.81, P < 0.001).
  • K(LV) was predicted accurately from E(DT) values with high correlation (r = 0.86, P < 0.001).

Structured PICO

Can early transmitral deceleration time (E(DT)) accurately estimate left ventricular operating stiffness (K(LV)) in humans?

P
Population
18 patients undergoing open-heart surgery
I
Intervention
Measurement of early transmitral deceleration time (E(DT)) via transesophageal echocardiography and Doppler flows
O
Outcome
Left ventricular operating stiffness (K(LV)) calculated from high-fidelity left atrial and left ventricular pressures and echocardiographic volumessurrogate

Early transmitral deceleration time provides an accurate, noninvasive estimate of left ventricular operating stiffness in adults with cardiac disease, supporting its use in evaluating diastolic function.

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Cite This Study

García et al. (2001) studied this question.

synapsesocial.com/papers/6a1d238428423f2ce504d0bchttps://doi.org/10.1152/ajpheart.2001.280.2.h554
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determination of Left Ventricular Chamber Stiffness From the Time for Deceleration of Early Left Ventricular Filling1995 · 306 citations
  2. 2Early mitral deceleration and left atrial stiffness2004 · 37 citations
  3. 3Chamber properties from transmitral flow: prediction of average and passive left ventricular diastolic stiffness2001 · 84 citations
  4. 4Noninvasive assessment of left ventricular end‐diastolic pressure by deceleration time of early diastolic mitral annular velocity in patients with heart failure2017 · 5 citations
  5. 5Quantitative Assessment of Left Ventricular Diastolic Stiffness in Man1973 · 66 citations