Why the study?
Long-term blood pressure measures indicate cardiovascular risks, but their associations with the development of dementia in later life needed examination.
Does high cumulative blood pressure or blood pressure variability in midlife increase the risk of developing dementia in later life?
Population
3201 individuals from the Framingham Heart Study
Comparison
Midlife cumulative blood pressure and visit-to-visit blood pressure variability patterns
Design
Cohort study
Authors
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Cumulative midlife SBP was associated with later dementia; extends prior cohorts but leaves BP variability's role and causality open.
Does high cumulative blood pressure or blood pressure variability in midlife increase the risk of developing dementia in later life?
High cumulative blood pressure during midlife is a strong predictor of dementia risk in later life, highlighting the importance of long-term blood pressure control.
Kim et al. (2023) studied this question.