Population
Two border disease virus (BDV) pairs each consisting of cytopathogenic (cp) and non-cp viruses
Comparison
Molecular and comparative sequence analysis vs Non-cytopathogenic (non-cp) BDV isolates
Design
Preclinical
Authors
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Cellular insertions correlate with BDV cytopathogenicity in animals; leaves open recombination mechanisms in related pestiviruses.
Cytopathogenicity of border disease virus is correlated with the integration of cellular sequences into the viral genome via RNA recombination.
Becher et al. (1996) studied this question.
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