Why the study?
Does type 2 diabetes alter metabolic and calcium homeostasis gene expression in patients with nonischemic heart failure?
Population
Left ventricular tissue from nonfailing hearts and from nonischemic failing hearts of patients with or…
Comparison
Type 2 diabetes (observational) vs Nondiabetic patients with nonischemic failing…
Design
Cross-sectional
Authors
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May indicate transcriptional basis for contractile dysfunction in diabetic HF; extends animal data but leaves open causal confirmation.
Does type 2 diabetes alter metabolic and calcium homeostasis gene expression in patients with nonischemic heart failure?
Downregulation of MEF2C and its regulated genes in diabetic failing hearts suggests a transcriptional mechanism contributing to contractile dysfunction in diabetic heart failure.
Razeghi et al. (2002) studied this question.
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