Key result
Plasma NT-proBNP levels were significantly elevated in patients with acute heart failure (8000 pg/mL) compared to healthy controls (90 pg/mL) and correlated with left ventricular ejection fraction.
Cross-Sectional (n=122)
Single-blind
No
Absolute Event Rate: 8000% vs 90%
p-value: p=<0.001
NT-proBNP levels are significantly elevated in acute heart failure and correlate with echocardiographic markers of severity such as LVEF and left ventricular diameters.
NT-proBNP elevation associates with acute HF severity; cross-sectional data leaves prospective validation open.
AIM: The aim of this study was to analyse the relation between clinical, haemodynamic and X-ray parameters and plasma NT-proBNP level in pts with symptoms of left ventricular dysfunction. METHODS: The plasma NT-proBNP levels, chest x-ray, transthoracic 2-d and Doppler echocardiography were performed at the time of admission in a group of 96 consecutive patients (mean age 68 +/- 11 years) with symptoms of acute heart failure. NT-proBNP levels were assessed with the use of commercial tests (Roche Diagnostics). RESULTS: All patients have significant increase in NT-proBNP (8000 +/- 9000 pg/mL vs. controls 90 +/- 80 pg/mL, p < 0.001). The group of all patients has shown a significant increase in cardiothoracic ratio (CTR, 0.6 +/- 0.1, vs. 0.4 +/- 0.1, p < 0.001), left atrium diameter (LAD, 4.4 +/- 0.8 cm, vs.3.5 +/- 0.4 cm, p < 0.01). Left ventricular ejection fraction (LVEF) was decreased (37 +/- 15%, vs. 64 +/- 5%, p < 0.001). In patients with acute heart failure, NT-proBNP significantly correlated with end-systolic and end-diastolic left ventricle diameters, ejection fraction, vena cava inferior diameter and plasma creatinine levels. CONCLUSION: Increased plasma NT-proBNP level is influenced by the clinical severity of acute heart failure and correlates with LVEF and IVCD. NT-proBNP can serve as a marker for the clinical severity of the disease.
No takes yet. Share an insight, caveat, or question.
Pudil et al. (2007) conducted a cross-sectional in Acute Heart Failure (n=122). NT-proBNP measurement vs. Healthy controls was evaluated on Plasma NT-proBNP level (pg/mL) (p=<0.001). Plasma NT-proBNP levels were significantly elevated in patients with acute heart failure (8000 pg/mL) compared to healthy controls (90 pg/mL) and correlated with left ventricular ejection fraction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: