What does this research mean for the field?

Lipoprotein lipase (LPL) associates with circulating lipoproteins through a specific protein-protein interaction with the amino-terminal region of apolipoprotein B (apoB). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1995Journal of Biological ChemistryOpen Access

Lipoprotein Lipase Association with Lipoproteins Involves Protein-Protein Interaction with Apolipoprotein B

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Population

In vitro biochemical models studying Lipoprotein Lipase and lipoproteins

Design

Preclinical

Authors

SCSungshin ChoiAmes Research Center SPSivaram PillarisettiRush University Medical Center DWDee E. WalkerColumbia University

Discussion

Member takes

Implication

Does not support clinical changes in lipid management; extends preclinical LPL-apoB mechanism and leaves translation open.

Structured PICO

Population

In vitro biochemical models (solid phase assays, ligand blots) studying Lipoprotein Lipase (LPL) and lipoproteins (LDL, VLDL, HDL, ApoB fragments)

Intervention

Assessment of LPL binding to lipoproteins and apolipoprotein B fragments

Outcome

LPL-lipoprotein complex formation and specific binding to ApoB regionssurrogate

The study demonstrates that Lipoprotein Lipase specifically interacts with the amino-terminal region of Apolipoprotein B, facilitating its association with circulating lipoproteins.

Cite This Study

Choi et al. (1995) studied this question.

synapsesocial.com/papers/6a1d705f73c56dd1bd2fae1b https://doi.org/10.1074/jbc.270.14.8081

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Lipoprotein Lipase Association with Lipoproteins Involves Protein-Protein Interaction with Apolipoprotein B

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lipoprotein Lipase Association with Lipoproteins Involves Protein-Protein Interaction with Apolipoprotein B

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider