What is the clinical evidence from this study?

Study design: Observational. Population: Non-ST segment elevation acute coronary syndrome (NSTE-ACS) with coronary slow flow phenomenon (n=111). Intervention: Neutrophil to lymphocyte ratio (NLR). Primary outcome: Recurrent myocardial infarction (HR 1.48, 95% CI 1.16-1.90, p=< 0.01).

What does this research mean for the field?

Higher neutrophil to lymphocyte ratio is independently associated with an increased risk of recurrent myocardial infarction and angina in patients presenting with non-ST segment elevation acute coronary syndrome and coronary slow flow phenomenon. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2021Journal of Cardiovascular and Thoracic ResearchOpen Access

Performance of neutrophil to lymphocyte ratio for the prediction of long-term morbidity and mortality in coronary slow flow phenomenon patients presented with non-ST segment elevation acute coronary syndrome

Q: What are the key findings of this study?

Higher neutrophil to lymphocyte ratio was independently associated with an increased risk of recurrent myocardial infarction (HR 1.48) in patients presenting with NSTE-ACS and coronary slow flow.

Q: What does this research mean for the field?

Higher neutrophil to lymphocyte ratio is independently associated with an increased risk of recurrent myocardial infarction and angina in patients presenting with non-ST segment elevation acute coronary syndrome and coronary slow flow phenomenon. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Higher neutrophil to lymphocyte ratio was independently associated with an increased risk of recurrent myocardial infarction (HR 1.48) in patients presenting with NSTE-ACS and coronary slow flow.

Why the study?

It was unknown whether the neutrophil to lymphocyte ratio could predict long-term morbidity and mortality in patients hospitalized for NSTE-ACS with coronary slow flow on coronary angiography.

Does a high neutrophil to lymphocyte ratio predict recurrent myocardial infarction in patients with NSTE-ACS and coronary slow flow phenomenon?

Population

111 patients hospitalized for NSTE-ACS with coronary slow flow on coronary angiography

Comparison

Three groups classified according to NLR values

Design

Observational study

Authors

AZAhmet ZenginSağlık Bilimleri Üniversitesi MKMehmet KaracaDiyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi EAEmre AruğaslanMemorial Ankara Hospital

Discussion

Member takes

Implication

NLR may identify higher recurrent MI risk in NSTE-ACS with slow flow; leaves open whether NLR-targeted interventions improve outcomes.

Study Design

Type

Observational (n=111)

Multicenter

Structured PICO

Does a high neutrophil to lymphocyte ratio predict recurrent myocardial infarction in patients with NSTE-ACS and coronary slow flow phenomenon?

Population

111 patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) and coronary slow flow phenomenon on coronary angiography, mean age 50.2, 67.5% male, based in Turkey. Excluded patients with coronary plaque, atherosclerotic lesion, coronary ectasia, heart failure, chronic renal or hepatic diseases, inflammatory or autoimmune diseases, malignancy, or infection.

Intervention

High neutrophil to lymphocyte ratio (NLR ≥ 3.88, highest tertile) measured at admission

Comparator

Lower neutrophil to lymphocyte ratio tertiles (Tertile 1: ≤ 1.87 and Tertile 2: 1.88-3.87)

Outcome

Occurrence of recurrent myocardial infarction at mean 35.4 months follow-uphard clinical

Main Result

Effect estimate: HR 1.48 (95% CI 1.16-1.90)

p-value: p=< 0.01

Limitations

Retrospective study design
Small sample size
Evaluated just one value of NLR rather than consecutive measurements
retrospective study
small sample size
evaluated just one value of NLR rather than consecutive measurements

Cite This Study

Zengin et al. (2021) conducted an observational in Non-ST segment elevation acute coronary syndrome (NSTE-ACS) with coronary slow flow phenomenon (n=111). Neutrophil to lymphocyte ratio (NLR) was evaluated on Recurrent myocardial infarction (HR 1.48, 95% CI 1.16-1.90, p=< 0.01). Higher neutrophil to lymphocyte ratio was independently associated with an increased risk of recurrent myocardial infarction (HR 1.48) in patients presenting with NSTE-ACS and coronary slow flow.

synapsesocial.com/papers/6a1d934c7328fa9a742fb412 https://doi.org/10.34172/jcvtr.2021.12

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Performance of neutrophil to lymphocyte ratio for the prediction of long-term morbidity and mortality in coronary slow flow phenomenon patients presented with non-ST segment elevation acute coronary syndrome

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Performance of neutrophil to lymphocyte ratio for the prediction of long-term morbidity and mortality in coronary slow flow phenomenon patients presented with non-ST segment elevation acute coronary syndrome

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider