Key result
In a 20-year follow-up of 17 family members with Marfan syndrome, the mortality rate was 11% (2 deaths), both resulting from traffic accidents rather than cardiovascular events.
Case Report (n=17)
No
This 20-year follow-up of a family with Marfan syndrome suggests that trauma, possibly secondary to acute visual disturbances, may be an under-recognized cause of mortality compared to classic cardiovascular events.
Alerts clinicians to possible non-cardiovascular mortality risks in Marfan syndrome; leaves open the role of visual disturbances in larger cohorts.
Marfan syndrome is a rare connective tissue disorder manifesting with cardiovascular pathologies which are also the leading cause of death. Herein, we present the past 20 years follow up of a family with 17 members afflicted with Marfan syndrome. 3 members of the family were deceased and none were due to cardiovascular events. We assume to some extent traumas are a neglected cause for a part of mortality in Marfan syndrome.
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Valizadeh et al. (2021) conducted a case report in Marfan syndrome (n=17). Observational follow-up was evaluated on Mortality rate. In a 20-year follow-up of 17 family members with Marfan syndrome, the mortality rate was 11% (2 deaths), both resulting from traffic accidents rather than cardiovascular events.
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