What does this research mean for the field?

Sympathoadrenal activity (epinephrine) is entrained to the sleep-wake cycle and selectively enhanced by awakening, whereas noradrenergic activity (norepinephrine) depends primarily on horizontal body position, with both branches being downregulated during REM sleep. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research aims to evaluate sympathetic nervous system activity related to sleep and waking periods in healthy individuals.

July 1, 1997Hypertension

Plasma Epinephrine and Norepinephrine Concentrations of Healthy Humans Associated With Nighttime Sleep and Morning Arousal

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Why the study?

How do plasma epinephrine and norepinephrine concentrations change during nocturnal sleep, REM sleep, and morning arousal in healthy young men?

Population

13 healthy men, age 18 to 35 years

Comparison

Nocturnal sleep, rapid eye movement sleep… vs Wakefulness before and after sleep, non-REM…

Follow-up

11 hours (9:30 PM to 8:30 AM)

Authors

CDChristoph DodtMünchen Klinik Bogenhausen UBUlrike BrecklingUniversity of Lübeck IDInge DeradUniversity of Lübeck

Discussion

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Implication

Sympathoadrenal patterns during sleep and arousal are hypothesis-generating in healthy men; prospective studies needed to assess links to morning CV risk.

Key Points

The research aims to evaluate sympathetic nervous system activity related to sleep and waking periods in healthy individuals.
Measured plasma epinephrine and norepinephrine every 7 minutes overnight in 13 healthy men (ages 18-35).
Monitored sleep through somnopolygraphy and continuously tracked heart rate and blood pressure.
Blood samples taken during sleep and at waking to assess changes in hormone levels.
Average epinephrine levels were significantly lower during sleep compared to wakefulness (p<0.01).
Epinephrine and norepinephrine were significantly lower during rapid eye movement sleep than during earlier stages (p<0.05).
Norepinephrine levels sharply increased by 180% upon standing, while epinephrine rose by 46% (p<0.01).

Structured PICO

How do plasma epinephrine and norepinephrine concentrations change during nocturnal sleep, REM sleep, and morning arousal in healthy young men?

Population

13 healthy men, age 18 to 35 years

Intervention

Nocturnal sleep, rapid eye movement (REM) sleep, morning awakening, and orthostasis (standing up)

Comparator

Wakefulness before and after sleep, non-REM sleep stages, and horizontal body position

Outcome

Plasma epinephrine and norepinephrine concentrationssurrogate

The study demonstrates that sympathoadrenal activity is downregulated during sleep and REM sleep, while morning awakening and subsequent orthostasis distinctly activate different branches of the sympathetic nervous system.

Cite This Study

Dodt et al. (1997) studied this question.

synapsesocial.com/papers/6a1d9917ba65f5ee325ea511 https://doi.org/10.1161/01.hyp.30.1.71

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Implication

Sympathoadrenal patterns during sleep and arousal are hypothesis-generating in healthy men; prospective studies needed to assess links to morning CV risk.

Plasma Epinephrine and Norepinephrine Concentrations of Healthy Humans Associated With Nighttime Sleep and Morning Arousal

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Plasma Epinephrine and Norepinephrine Concentrations of Healthy Humans Associated With Nighttime Sleep and Morning Arousal

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider