Key result
Plasma epinephrine and norepinephrine demonstrated significant diurnal rhythms, with norepinephrine responding directly to posture and sleep, while epinephrine is likely controlled by a circadian oscillator.
Observational
Effect estimate: r = 0.49
This physiological study demonstrates that epinephrine follows a true circadian oscillator, whereas norepinephrine variations are primarily driven by changes in posture and sleep.
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Timing of catecholamine sampling should account for posture and sleep; leaves open whether epinephrine's circadian control informs chronotherapy trials.
Linsell et al. (1985) conducted an observational in Healthy. Time of day, sleep, and posture was evaluated on Diurnal rhythms of plasma epinephrine and norepinephrine (r = 0.49). Plasma epinephrine and norepinephrine demonstrated significant diurnal rhythms, with norepinephrine responding directly to posture and sleep, while epinephrine is likely controlled by a circadian oscillator.
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