Key result
Skeletal muscle abnormalities and adipose tissue dysfunction are hallmarks of heart failure that can be targeted through lifestyle interventions, exercise mimetics, and myokines.
Why the study?
Skeletal muscle abnormalities are a hallmark of HF and impair activities of daily living and quality of life, but the associations between lipid metabolism, adipose tissue, and muscle dysfunction require further exploration.
Design
Review
Authors
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Should not yet alter heart failure management; leaves open whether targeting muscle and adipose dysfunction improves outcomes in trials.
Skeletal muscle and lipid metabolism abnormalities are key drivers of exercise intolerance in heart failure, offering practical therapeutic targets through lifestyle and pharmacological interventions.
Takada et al. (2020) conducted a review in Heart Failure. Skeletal muscle abnormalities and adipose tissue dysfunction are hallmarks of heart failure that can be targeted through lifestyle interventions, exercise mimetics, and myokines.
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