Key result
Cancer is linked to higher post-MI mortality and bleeding, with worse outcomes in women.
Why the study?
Most cardiology trials and registries exclude cancer patients, leaving limited data on coronary artery disease in cancer, particularly regarding outcomes and management in women.
Does concomitant cancer affect the treatment and prognosis of coronary artery disease, and are there gender differences?
Does concomitant cancer affect the treatment and prognosis of coronary artery disease, and are there gender differences?
This review highlights the increased cardiovascular risks in cancer patients and emphasizes that cancer should not be a general exclusion criterion for interventional CAD treatments, though gender disparities persist.
Elevated post-MI risks in cancer patients, especially women, warrant careful monitoring; leaves optimal strategies open pending prospective trials.
Cardiovascular disease and cancer remain the leading causes of hospitalization and mortality in high-income countries. Survival after myocardial infarction has improved but there is still a difference in clinical outcome, mortality, and developing heart failure to the disadvantage of women with myocardial infarction. Most major cardiology trials and registries have excluded patients with cancer. As a result, there is only very limited information on the effects of coronary artery disease in cancer patients. In particular, the outcomes in women with cancer and coronary artery disease and its management remain empiric. We reviewed studies of over 27 million patients with coronary artery disease and cancer. Our review focused on the most important types of cancer (breast, colon, lung, prostate) and hematological malignancies with particular attention to sex-specific differences in treatment and prognosis.
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Lange et al. (2022) conducted a review in Coronary artery disease and cancer (n=27,000,000). Concomitant cancer vs. No cancer or historical cancer was evaluated on Clinical outcomes, mortality, and bleeding. Cancer patients with myocardial infarction have higher mortality and bleeding risks compared to those without cancer, and women remain disadvantaged in treatment and prognosis.
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