Acute myocardial infarction: association with time since stopping smoking in Italy. GISSI-EFRIM Investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto. Epidemiologia dei Fattori di Rischio dell'Infarto Miocardico.
Why the study?
Does stopping smoking reduce the risk of acute myocardial infarction compared to current smoking?
Population
2,022 subjects
Comparison
Time since stopping smoking and current smoking vs Never smokers
Design
Case-control
Authors
Discussion
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Member takes
Implication
Quitting was associated with rapid AMI risk drop; extends observational data but leaves open causality and practice change.
Structured PICO
Does stopping smoking reduce the risk of acute myocardial infarction compared to current smoking?
P
Population
2,022 subjects (916 incident cases of acute myocardial infarction below age 75 years with no history of ischaemic heart disease, and 1,106 control subjects admitted for acute, non-neoplastic, cardiovascular or cerebrovascular conditions not related to smoking)
I
Intervention
Time since stopping smoking (ex-smokers: 1 year, 2-5 years, 6-10 years, >10 years) and current smoking
C
Comparator
Never smokers
O
Outcome
Risk of acute myocardial infarction (relative risk)hard clinical
Smoking cessation leads to a substantial reduction in the risk of acute myocardial infarction within one year, supporting the immediate cardiovascular benefits of quitting.
Cite This Study
Negri et al. (1994) studied this question.