Key result
Current cigarette smoking in women was associated with a dose-dependent increased risk of myocardial infarction, with relative risks up to 11.0 for smoking ≥25 cigarettes per day.
Why the study?
Does cigarette smoking increase the risk of acute myocardial infarction in young and middle-aged women?
Case-Control (n=781)
Yes
Does cigarette smoking increase the risk of acute myocardial infarction in young and middle-aged women?
Cigarette smoking is a major, dose-dependent risk factor for myocardial infarction in young and middle-aged women, accounting for nearly half of all cases in this population.
Supports targeted smoking cessation in young women; leaves open causal confirmation from prospective studies.
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Gramenzi et al. (1989) conducted a case-control in myocardial infarction (n=781). Cigarette smoking vs. Life long non-smokers was evaluated on myocardial infarction (RR 2.3, 5.9, and 11.0 for <15, 15-24, and ≥25 cigarettes per day). Current cigarette smoking in women was associated with a dose-dependent increased risk of myocardial infarction, with relative risks up to 11.0 for smoking ≥25 cigarettes per day.
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