Key result
Smoking is linked to higher MI risk in women under 50, augmented by oral contraceptives.
Why the study?
The modifying influence of individual risk factors on the relation between myocardial infarction and cigarette smoking in women younger than 50 years was unclear.
Does cigarette smoking increase the risk of myocardial infarction in women younger than 50 years of age?
Population
555 women with first MI and 1,864 hospital controls younger than 50 years
Comparison
Cigarette smoking vs non-smoking or lower levels of smoking
Design
Case-control study
Authors
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Supports smoking cessation counseling in young women on OCs; extends prior associations but remains hypothesis-generating from case-control data.
Case-Control (n=2,419)
Does cigarette smoking increase the risk of myocardial infarction in women younger than 50 years of age?
Cigarette smoking is a strong, independent risk factor for myocardial infarction in young women, and its risk is synergistically amplified by concurrent oral contraceptive use or hypercholesterolemia.
L. Rosenberg (1985) conducted a case-control in Myocardial infarction (n=2,419). Cigarette smoking vs. Non-smokers or lower number of cigarettes smoked was evaluated on Myocardial infarction. Cigarette smoking increased the risk of myocardial infarction in women younger than 50 years of age across all risk factor profiles, with the risk augmented by recent oral contraceptive use.
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