Key result
Smoking and hypertension demonstrated a synergistic effect on the incidence of myocardial infarction in women (RR 12.2; 95% CI 7.5-19.8 compared to normotensive never-smokers).
Why the study?
How do other cardiovascular risk factors modify the risk of myocardial infarction in middle-aged female smokers?
Population
10,619 women, mean age 48.3 +/- 8.2 years
Comparison
Smoking combined with other cardiovascular risk… vs Never-smokers and smokers without additional…
Design
Cohort
Follow-up
mean 14 years
Authors
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May inform risk stratification among female smokers; leaves open whether modifying hypertension alters this interaction.
Cohort (n=10,619)
How do other cardiovascular risk factors modify the risk of myocardial infarction in middle-aged female smokers?
Relative Risk: 12.2 (95% CI 7.5–19.8)
Cardiovascular risk factors such as hypertension and diabetes synergistically increase the risk of myocardial infarction in female smokers, highlighting the need for comprehensive risk factor management.
Janzon et al. (2004) conducted a cohort in Myocardial infarction (n=10,619). Smoking and hypertension vs. Normotensive never-smokers was evaluated on Incidence of MI (fatal and nonfatal) (RR 12.2, 95% CI 7.5-19.8). Smoking and hypertension demonstrated a synergistic effect on the incidence of myocardial infarction in women (RR 12.2; 95% CI 7.5-19.8 compared to normotensive never-smokers).
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