Key result
Heavy smoking linked to a ~10-fold higher risk of first nonfatal MI in young women.
Why the study?
Risk factors for first nonfatal myocardial infarction in women younger than age 50 years were not fully characterized.
What are the primary risk factors associated with first nonfatal myocardial infarction in women under 50 years of age?
Population
255 women with first nonfatal MI and 802 controls under age 50
Comparison
Presence vs absence of cardiovascular risk factors
Design
Case-control study
Authors
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Heavy smoking elevates MI risk in young women; extends case-control data on modifiable factors but leaves open prospective confirmation.
Case-Control (n=1,057)
What are the primary risk factors associated with first nonfatal myocardial infarction in women under 50 years of age?
Relative Risk: 10
Cigarette smoking is the most prominent and modifiable risk factor for first nonfatal myocardial infarction in young women.
Lynn A. Rosenberg (1983) conducted a case-control in first nonfatal myocardial infarction (n=1,057). Cigarette smoking vs. Never smoked was evaluated on first nonfatal myocardial infarction (RR 10). Current smoking of 35 or more cigarettes per day was associated with a ten-fold increased risk of first nonfatal myocardial infarction in women under 50 compared to never smoking.
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