Why the study?
Does isolated low-dose oral prazosin improve hemodynamic function in patients with congestive heart failure?
Does isolated low-dose oral prazosin improve hemodynamic function in patients with congestive heart failure?
Isolated low-dose oral prazosin significantly reduces preload and afterload while increasing cardiac index in patients with congestive heart failure.
Hypothesis-generating for low-dose prazosin in HF; leaves open need for RCTs before any practice consideration.
Prazosin was administered orally at a maximal dose of 2 mg every 6 hours to 4 patients with congestive heart failure (CHF) who had not received either digitalis or diuretics for 72 hours before therapy. Three of the 4 patients had hypertensive and arteriosclerotic heart disease. Hemodynamic monitoring in dicated a significant reduction of preload and afterload with a concomitant rise in the cardiac index. We concluded that isolated low-dose oral prazosin has salutary effects on indices of hemodynamic function in selected patients.
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Reyns et al. (1979) studied this question.
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