What does this research mean for the field?

Patients with heart failure with mid-range ejection fraction (HFmrEF) share clinical characteristics similar to those with reduced ejection fraction (HFrEF), while their echocardiographic features and incidence of adverse outcomes are intermediate between HFrEF and preserved ejection fraction (HFpEF). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 10, 2021Kazan medical journalOpen Access

Heart failure patients with mid-range ejection fraction: clinical features and prognosis

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Why the study?

To analyze clinical and echocardiographic characteristics and prognosis in patients with heart failure with mid-range ejection fraction.

Structured PICO

Population

76 patients with stable heart failure I-IV functional class, mean age 66.1 years. Divided into 3 subgroups based on LVEF: HFrEF (<40%, n=16), HFmrEF (40-49%, n=18), and HFpEF (>50%, n=42).

Outcome

Composite of cardiovascular mortality, myocardial infarction, stroke, hospitalization for acutely decompensated heart failure, and thrombotic complications at 1 yearcomposite

Patients with HFmrEF exhibit clinical characteristics similar to HFrEF but have an intermediate echocardiographic profile and prognosis compared to HFrEF and HFpEF.

Limitations

small sample size

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Similar event rates across HF phenotypes warrant no change in risk stratification; leaves open whether HFmrEF requires distinct management in larger studies.

Cite This Study

Bulashova et al. (2021) studied this question.

synapsesocial.com/papers/6a1e084f520f01455d601d7b https://doi.org/10.17816/kmj2021-293

Topics

HFrEF treatment Echocardiography Heart failure Heart failure hospitalization HFpEF management

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Implication

Similar event rates across HF phenotypes warrant no change in risk stratification; leaves open whether HFmrEF requires distinct management in larger studies.

Heart failure patients with mid-range ejection fraction: clinical features and prognosis

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Heart failure patients with mid-range ejection fraction: clinical features and prognosis

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider