What does this research mean for the field?

The M110 and M21 regulatory subunits of smooth muscle protein phosphatase-1M contain distinct structural motifs, including ankyrin repeats in M110 and a leucine zipper in M21, with one of the two expressed forms of M110 being highly homologous to the entire M21 subunit. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 14, 1994FEBS LettersOpen Access

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M

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Population

Rat aorta and chicken gizzard (smooth muscle)

Design

Preclinical

Authors

YCYu Hua ChenSemmelweis University MCMao Xiang ChenGlaxoSmithKline (United Kingdom)DADario R. AlessiTokyo Medical and Dental University

Discussion

Member takes

Implication

No immediate clinical implications from animal data; extends PP1M structural knowledge and leaves open human functional validation.

Structured PICO

Population

Rat aorta and chicken gizzard (smooth muscle)

Intervention

Molecular cloning of cDNA

Outcome

Deduced structures of M110 and M21 regulatory subunits of protein phosphatase-1M

The study identifies the structural motifs of the M110 and M21 regulatory subunits of smooth muscle protein phosphatase-1M, providing insights into its regulatory mechanisms.

Cite This Study

Chen et al. (1994) studied this question.

synapsesocial.com/papers/6a1e40bf7f6e8bbb2368aff1 https://doi.org/10.1016/0014-5793(94)01231-8

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Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider