Why the study?
Does captopril reduce blood pressure in hypertensive patients receiving diuretic therapy?
Population
8 hypertensive patients with normal renal function receiving diuretic therapy for at least 28 days
Comparison
Captopril in small increasing doses vs Baseline (before captopril administration)
Design
Case_series
Follow-up
Acute (minutes to hours post-dose)
Authors
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May lower BP in diuretic-treated hypertensives; case report leaves open need for controlled trials.
Does captopril reduce blood pressure in hypertensive patients receiving diuretic therapy?
Captopril effectively lowers blood pressure in diuretic-treated hypertensive patients, with the duration of the hypotensive effect being dose-dependent.
Harris Koffer (1980) studied this question.