What question did this study set out to answer?

To determine whether clotting factors XI and IX, as well as contact system and common pathway components, are activated in patients experiencing acute coronary syndromes.

November 1, 2000Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Activation of Clotting Factors XI and IX in Patients With Acute Myocardial Infarction

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Authors

MMMonique C. MinnemaUniversity of Applied Sciences Utrecht RPRon J.G. PetersInterventional Cardiology RWRobbert de WinterUniversity of Graz

Discussion

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Implication

Prospective study demonstrates activation of clotting factors XI and IX in acute coronary syndromes, indicating their role in thrombin generation and clot stability.

Key Points

To determine whether clotting factors XI and IX, as well as contact system and common pathway components, are activated in patients experiencing acute coronary syndromes.
Prospectively evaluated 150 participants categorized into acute myocardial infarction (n=50), unstable angina pectoris (n=50), and stable angina pectoris (n=50).
Measured plasma levels of factor XIa-inhibitor complexes, factor IX activation peptide, fibrinopeptide A, and factor XIIa- or kallikrein-C1 inhibitor complexes.
Factor XIa-C1 inhibitor complexes reflecting acute activation were detected in 24% of AMI, 8% of UAP, and 4% of SAP patients (P<0.05), whereas chronic factor XIa-alpha(1)-antitrypsin complexes did not differ across groups.
Factor IX peptide levels were significantly higher in AMI and UAP compared to SAP (P<0.01), and fibrinopeptide A levels were elevated in AMI versus UAP and SAP (P<0.01).
No significant increases were observed in common pathway markers or factor XIIa- and kallikrein-C1 inhibitor complexes.

Cite This Study

Minnema et al. (2000) studied this question.

synapsesocial.com/papers/6a1e7fb740bc8a3dd768fb5b https://doi.org/10.1161/01.atv.20.11.2489

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Implication

Prospective study demonstrates activation of clotting factors XI and IX in acute coronary syndromes, indicating their role in thrombin generation and clot stability.

Activation of Clotting Factors XI and IX in Patients With Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

Activation of Clotting Factors XI and IX in Patients With Acute Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

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