Why the study?
Does efonidipine improve blood pressure and proteinuria in partially nephrectomized spontaneously hypertensive rats compared to control or nifedipine?
Population
44 spontaneously hypertensive rats (SHR) with 5 of 6 nephrectomy, fed a high-salt diet (5% NaCl)
Comparison
Efonidipine, enalapril, or nifedipine… vs Control group (n=20) receiving no active treatment
Design
Preclinical
Follow-up
8 weeks
Authors
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Efonidipine may confer proteinuria protection beyond BP reduction in hypertensive rats; leaves open translation to human CKD.
Does efonidipine improve blood pressure and proteinuria in partially nephrectomized spontaneously hypertensive rats compared to control or nifedipine?
Efonidipine, unlike nifedipine, attenuates both systolic blood pressure increase and proteinuria in a rat model of hypertensive renal failure, possibly due to efferent arteriolar dilation.
Fujiwara et al. (1998) studied this question.
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