What does this research mean for the field?

In essential hypertension, ACE inhibitors reduce albuminuria more consistently than calcium antagonists despite similar systemic blood pressure reductions, and transferrinuria is not a useful marker for early glomerular dysfunction in these patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1996American Journal of HypertensionOpen Access

Albuminuria and Transferrinuria in Essential HypertensionEffects of Antihypertensive Therapy

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Why the study?

Does fosinopril compared to amlodipine improve urinary albumin and transferrin excretion in never-treated patients with essential hypertension?

Population

24 never-treated patients with essential hypertension and normal renal function, mean age 46.4 +/- 8.9 years.

Comparison

Fosinopril vs Amlodipine

Design

RCT, randomly received amlodipine or fosinopril

Follow-up

6 months

Authors

CAC AlliMassachusetts General Hospital MLMauro LombardoSan Raffaele University of Rome DZD. ZanniAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Discussion

Member takes

Implication

Fosinopril may be preferred over amlodipine to reduce albuminuria in essential hypertension despite similar BP lowering; confirms ACE inhibitor renoprotection beyond systemic effects.

Structured PICO

Does fosinopril compared to amlodipine improve urinary albumin and transferrin excretion in never-treated patients with essential hypertension?

Population

24 never-treated patients with essential hypertension (diastolic blood pressure between 90 and 114 mm Hg) and normal renal function, mean age 46.4 +/- 8.9 years.

Intervention

Fosinopril (with doxazosin added if diastolic blood pressure was not normalized)

Comparator

Amlodipine (with doxazosin added if diastolic blood pressure was not normalized)

Outcome

Urinary albumin and transferrin excretion and their relationship to blood pressure at 3 and 6 monthssurrogate

In essential hypertension, fosinopril reduces albuminuria more consistently than amlodipine, suggesting intrarenal hemodynamic changes play a key role beyond systemic blood pressure reduction.

Cite This Study

Alli et al. (1996) studied this question.

synapsesocial.com/papers/6a1e8ac00a6b1b87af954d21 https://doi.org/10.1016/0895-7061(96)00237-3

Topics

Hypertension management

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Implication

Fosinopril may be preferred over amlodipine to reduce albuminuria in essential hypertension despite similar BP lowering; confirms ACE inhibitor renoprotection beyond systemic effects.

Albuminuria and Transferrinuria in Essential HypertensionEffects of Antihypertensive Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Albuminuria and Transferrinuria in Essential HypertensionEffects of Antihypertensive Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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