Why the study?
Does amlodipine plus fosinopril combination reduce urinary albumin excretion more than monotherapy in hypertensive patients with type 2 diabetes and microalbuminuria?
Population
453 hypertensive patients with type 2 diabetes and microalbuminuria
Comparison
Amlodipine plus fosinopril combination for 4 years vs Amlodipine monotherapy or fosinopril monotherapy
Design
RCT, randomized
Follow-up
4 years
Authors
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Supports initial amlodipine-fosinopril combination in diabetic hypertension with microalbuminuria; extends prior monotherapy comparisons in this population.
Does amlodipine plus fosinopril combination reduce urinary albumin excretion more than monotherapy in hypertensive patients with type 2 diabetes and microalbuminuria?
The combination of amlodipine and fosinopril is more effective than either monotherapy in reducing blood pressure, microalbuminuria, and cardiovascular events in hypertensive patients with type 2 diabetes.
R Fogari (2002) studied this question.
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