Why the study?
Does enalapril reduce urinary albumin excretion compared to nitrendipine in patients with essential hypertension?
Population
24 patients with essential hypertension
Comparison
Enalapril 20 mg/day for 8 weeks vs Nitrendipine 20 to 40 mg/day for 8 weeks
Design
RCT, Randomly divided into two groups of 12
Follow-up
16 weeks (8 weeks per treatment phase)
Authors
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Supports ACE inhibitor preference over CCBs for microalbuminuria in essential hypertension; extends evidence for BP-independent renoprotective effects.
Does enalapril reduce urinary albumin excretion compared to nitrendipine in patients with essential hypertension?
Enalapril, but not nitrendipine, reduces microalbuminuria in patients with essential hypertension despite similar blood pressure lowering effects.
Bianchi et al. (1991) studied this question.
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