What does this research mean for the field?

Q: What does this research mean for the field?

Aldosterone is a critical mediator of angiotensin II and L-NAME-induced cardiovascular and renal damage, acting through mechanisms independent of its effects on systolic blood pressure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 2000EndocrinologyOpen Access

Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy

View Full Paper

Ask AI

Bookmark

Why the study?

Does aldosterone removal or antagonism reduce myocardial and renal vascular damage in a rat model of L-NAME/angiotensin II-induced injury?

Population

Male rats drinking 1% saline treated with angiotensin II and N-nitro-L-arginine methyl ester to induce…

Comparison

Removal of aldosterone by adrenalectomy or… vs L-NAME/angiotensin II-treated animals without…

Design

Preclinical

Authors

RRRicardo RochaMansfield University

Discussion

Member takes

Implication

Aldosterone antagonism may limit cardiac/renal injury independent of BP; animal data leave open translation to human hypertension trials.

Structured PICO

Does aldosterone removal or antagonism reduce myocardial and renal vascular damage in a rat model of L-NAME/angiotensin II-induced injury?

Population

Male rats drinking 1% saline treated with angiotensin II and N-nitro-L-arginine methyl ester (L-NAME) to induce cardiac injury and hypertension.

Intervention

Removal of aldosterone by adrenalectomy or administration of the selective aldosterone antagonist eplerenone; and aldosterone infusion in adrenalectomized, glucocorticoid-replaced animals.

Comparator

L-NAME/angiotensin II-treated animals without aldosterone removal or antagonism.

Outcome

Cardiac and renal damage (including biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels) and systolic blood pressure.surrogate

Aldosterone is a critical mediator of L-NAME/angiotensin II-induced vascular and myocardial damage through mechanisms independent of its effects on systolic blood pressure.

Cite This Study

Ricardo Rocha (2000) studied this question.

synapsesocial.com/papers/6a1ea5d3989adebfe89a6705 https://doi.org/10.1210/en.141.10.3871

View Full Paper

Ask AI

Bookmark

Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider