Key result
The literature review highlights the overlapping pathogenetic pathways of atherosclerosis and depression, particularly the role of intestinal microbiota in modulating systemic inflammation.
Why the study?
The literature review was conducted to identify novel cardiovascular risk factors that complement classic causes, focusing on depressive disorders, chronic stress, systemic inflammation, and the gut microbiota.
Shared pathogenetic pathways, including gut microbiota and systemic inflammation, link atherosclerosis and depression, potentially offering new therapeutic targets.
Answers are grounded in this paper and cite their sources.
May inform microbiota-focused trials in comorbid atherosclerosis and depression; hypothesis-generating without practice implications.
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Смирнова et al. (2022) conducted a review in Atherosclerosis and depression. Intestinal microbiota and systemic inflammation was evaluated. The literature review highlights the overlapping pathogenetic pathways of atherosclerosis and depression, particularly the role of intestinal microbiota in modulating systemic inflammation.
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