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December 1, 2006Pediatric Diabetes

Type 2 diabetes and prediabetes in Hispanic adults were associated with reduced and delayed peak brachial artery diameter increases during postischemic hyperemia compared with healthy adults.

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Why the study?

How does postischemic vascular reactivity differ among Hispanic children and adults with varying glucose tolerance statuses?

Population

222 Hispanic individuals with and without type 2 diabetes mellitus or impaired glucose tolerance

Comparison

Assessment of endothelial function using… vs Comparisons between healthy, obese, and diabetic…

Design

Cross-sectional

Key result

Type 2 diabetes and prediabetes in Hispanic adults were associated with reduced and delayed peak brachial artery diameter increases during postischemic hyperemia compared with healthy adults.

Authors

EWEstela WajcbergNTNimmi ThoppilSPS. S. Patel

Discussion

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Member takes

Overview

Impaired postischemic vasodilation in Hispanic adults with dysglycemia should not change practice; leaves open pediatric patterns and prospective cardiovascular risk links.

Study Design

Type

Cross-Sectional (n=222)

Structured PICO

How does postischemic vascular reactivity differ among Hispanic children and adults with varying glucose tolerance statuses?

P
Population
222 Hispanic children and adults with and without type 2 diabetes mellitus, obesity, or impaired glucose tolerance.
E
Exposure
Assessment of endothelial function using high-resolution ultrasonography during postischemic hyperemic response
C
Comparator
Comparisons between healthy, obese, and diabetic children, and between healthy, impaired glucose tolerance, and diabetic adults
O
Outcome
Postischemic vascular reactivity (flow velocity, brachial artery diameter, and blood flow during hyperemic response)surrogate

The study identifies distinct abnormalities in flow-mediated vasodilation among diabetic and prediabetic Hispanic individuals, with differing vascular response patterns between children and adults.

Cite This Study

Wajcberg et al. (2006) conducted a cross-sectional in Type 2 diabetes mellitus (n=222). Type 2 diabetes mellitus and prediabetes vs. Healthy/lean subjects was evaluated on Postischemic hyperemic response (flow velocity and brachial artery diameter). Type 2 diabetes and prediabetes in Hispanic adults were associated with reduced and delayed peak brachial artery diameter increases during postischemic hyperemia compared with healthy adults.

synapsesocial.com/papers/6a1efdbd08df8bb755b30666https://doi.org/10.1111/j.1399-5448.2006.00209.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.1999 · 653 citations
  2. 2Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm1996 · 259 citations
  3. 3Close Relationship of Abnormal Glucose Tolerance With Endothelial Dysfunction in Hypertension2000 · 37 citations
  4. 4Endothelial Dysfunction Is Associated With Cholesterol Levels in the High Normal Range in Humans1997 · 208 citations
  5. 5Regulatory Functions of the Vascular Endothelium1990 · 1,901 citations