Key result
Herpes simplex virus type 1 infection caused a pronounced reduction in the cytoplasmic levels of moderately abundant mRNAs in polyoma-transformed BHK cells.
Herpes simplex virus type 1 infection alters cellular RNA processing in polyoma-transformed BHK cells by reducing cytoplasmic levels of moderately abundant mRNAs.
HSV-1 may alter host RNA processing in transformed cells; hypothesis-generating and leaves open relevance to primary or human cells.
Polyoma-transformed BHK cells are permissive for the replication of herpes simplex virus type 1. The effect of herpes infection on the steady-state levels of bulk mRNA sequences in these cells was studied by using cDNA to polyadenylated cytoplasmic RNA from uninfected cells. The principal findings were: (i) herpes simplex virus type 1 infection caused a pronounced reduction in the cytoplasmic levels of moderately abundant mRNAs' (ii) after infection, increased amounts of RNA complementary to the cDNA were isolated as part of the nonadenylated cytoplasmic RNA fraction.
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Nakai et al. (1982) studied Herpesvirus infection in BHK cells. Herpes simplex virus type 1 infection vs. Uninfected cells was evaluated on Steady-state levels of cellular polyadenylated RNA. Herpes simplex virus type 1 infection caused a pronounced reduction in the cytoplasmic levels of moderately abundant mRNAs in polyoma-transformed BHK cells.
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