What question did this study set out to answer?

To investigate the absorption, distribution, metabolism, and excretion pathways of hydrochlorothiazide following oral and intravenous administration in humans.

May 1, 1976Clinical Pharmacology & Therapeutics

Absorption, metabolism, and excretion of hydrochlorothiazide

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Authors

BBB BeermannNational Board of Health and Welfare MGMargaretha Groschinsky‐GrindNational Board of Health and Welfare ARAnders RosénLinköping University

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Implication

Pharmacokinetic investigation reveals substantial oral absorption and primarily unchanged renal excretion of hydrochlorothiazide in humans, suggesting stable elimination kinetics.

Key Points

To investigate the absorption, distribution, metabolism, and excretion pathways of hydrochlorothiazide following oral and intravenous administration in humans.
Administered radiolabeled 14C-hydrochlorothiazide orally (n=4) or intravenously (n=2) to healthy subjects, with additional oral testing in chronically treated hypertensive patients (n=3).
Measured plasma levels, blood cell accumulation, and excretion routes using radioactivity tracking and gas-liquid chromatography.
Gastrointestinal absorption reached 60% to 80% mostly in the duodenum and upper jejunum, with plasma levels declining in a two-compartment model showing half-lives of 1.7 hours (alpha-phase) and 13.1 hours (beta-phase).
Over 95% of absorbed or injected hydrochlorothiazide was eliminated unchanged in the urine, with hydrochlorothiazide accumulating preferentially in blood cells at an average cell-to-plasma ratio of 3.5.
Hypertensive patients handled single doses similarly to healthy subjects, though one patient with elevated serum creatinine demonstrated slower drug elimination.

Cite This Study

Beermann et al. (1976) studied this question.

synapsesocial.com/papers/6a1f0f5008df8bb755b319d8 https://doi.org/10.1002/cpt1976195part1531

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Implication

Pharmacokinetic investigation reveals substantial oral absorption and primarily unchanged renal excretion of hydrochlorothiazide in humans, suggesting stable elimination kinetics.

Absorption, metabolism, and excretion of hydrochlorothiazide

Discussion

Member takes

Implication

Key Points

Cite This Study

Absorption, metabolism, and excretion of hydrochlorothiazide

Discussion

Member takes

Implication

Key Points

Cite This Study

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