Key result
A population pharmacokinetic model demonstrated that creatinine clearance is a significant predictor of hydrochlorothiazide renal clearance, which decreases progressively with renal impairment.
Why the study?
How does creatinine clearance affect the pharmacokinetics of hydrochlorothiazide in healthy subjects and patients with fluid overload conditions?
Population
Healthy subjects and patients with renal failure, congestive heart failure (CHF), or hypertension
Design
Meta-analysis
Authors
Loading...
May support creatinine clearance-guided hydrochlorothiazide dosing in renal impairment; leaves open prospective validation in fluid overload.
Meta-Analysis
How does creatinine clearance affect the pharmacokinetics of hydrochlorothiazide in healthy subjects and patients with fluid overload conditions?
A population pharmacokinetic model of hydrochlorothiazide shows that its renal clearance is directly proportional to creatinine clearance, which can help optimize dosing in patients with renal impairment and fluid overload.
Wart et al. (2013) conducted a meta-analysis in Healthy subjects and patients with renal failure, congestive heart failure, or hypertension. Hydrochlorothiazide was evaluated on Time-course of hydrochlorothiazide concentrations in plasma and excretion into the urine. A population pharmacokinetic model demonstrated that creatinine clearance is a significant predictor of hydrochlorothiazide renal clearance, which decreases progressively with renal impairment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: