Key result
Ganglion blockade with trimethaphan virtually abolished R-R variability and reduced very low and low frequency blood pressure variability by 84% and 69%, respectively.
Why the study?
Does ganglion blockade with trimethaphan alter blood pressure and R-R variability in healthy subjects?
Population
10 healthy subjects, mean age 30 +/- 6 years
Comparison
Ganglion blockade with trimethaphan vs Baseline (before ganglion blockade)
Design
Other
Authors
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Informs mechanistic models of variability in health; leaves open applicability to clinical populations.
Does ganglion blockade with trimethaphan alter blood pressure and R-R variability in healthy subjects?
This study demonstrates that R-R variability is predominantly driven by autonomic neural activity, whereas blood pressure variability is mediated by a combination of neural activity, intrinsic vasomotor rhythmicity, and mechanical effects of respiration.
Zhang et al. (2002) studied Healthy (n=10). Ganglion blockade with trimethaphan vs. Baseline (before blockade) was evaluated on Blood pressure and R-R variability (spectral power). Ganglion blockade with trimethaphan virtually abolished R-R variability and reduced very low and low frequency blood pressure variability by 84% and 69%, respectively.
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