PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
May 1, 1995AJP Cell Physiology

Distribution of the Na+/Ca2+ exchange protein in developing rabbit myocytes

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated myocytes from immature (5, 11, 17, and 30 days) and adult rabbits

Design

Preclinical

Key result

The Na+/Ca2+ exchange protein is abundantly localized to the peripheral sarcolemma before and during the development of the T tubule system in developing rabbit myocytes.

Authors

FCF. ChenGMGiuliano A. MottinoTKThomas S. Klitzner

Discussion

Loading...

Member takes

Overview

NCX sarcolemmal localization in developing rabbit myocytes leaves open its role in human T-tubule maturation and calcium handling.

Structured PICO

P
Population
Isolated myocytes from immature (5, 11, 17, and 30 days) and adult rabbits.
E
Exposure
Indirect immunofluorescent studies using a monoclonal antibody to the Na+/Ca2+ exchanger followed by fluorescein-labeled goat anti-mouse antibody
O
Outcome
Localization of the Na+/Ca2+ exchangersurrogate

The Na+/Ca2+ exchange protein is abundantly localized to the peripheral sarcolemma before and during the development of the T tubule system in rabbit myocytes.

Cite This Study

Chen et al. (1995) studied this question. Indirect immunofluorescent labeling was evaluated on Localization of the Na+/Ca2+ exchanger. The Na+/Ca2+ exchange protein is abundantly localized to the peripheral sarcolemma before and during the development of the T tubule system in developing rabbit myocytes.

synapsesocial.com/papers/6a1f50e8f7f3ed4f5f23429dhttps://doi.org/10.1152/ajpcell.1995.268.5.c1126
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excitation-contraction coupling in neonatal and adult myocardium of cat1982 · 109 citations
  2. 2Steady-state mRNA levels of the sarcolemmal Na(+)-Ca2+ exchanger peak near birth in developing rabbit and rat hearts.1994 · 122 citations
  3. 3Distribution of the Na(+)-Ca2+ exchange protein in mammalian cardiac myocytes: an immunofluorescence and immunocolloidal gold-labeling study1992 · 200 citations
  4. 4Molecular Cloning and Functional Expression of the Cardiac Sarcolemmal Na + -Ca 2+ Exchanger1990 · 746 citations
  5. 5Developmental changes in cardiac myocyte calcium regulation.1990 · 79 citations