Key result
Regional ischemia impaired active relaxation and increased the sensitivity of the relaxation rate to volume during left ventricular filling in open-chest pigs.
Why the study?
Does regional ischemia alter the rate, duration, and extent of left ventricular relaxation in open-chest pigs?
Population
Open-chest pigs instrumented with high-fidelity pressure transducers
Comparison
Regional ischemia vs Normal perfusion
Design
Preclinical
Authors
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Regional ischemia effects on LV relaxation remain hypothesis-generating in animals; leaves open translation to human diastolic assessment.
Does regional ischemia alter the rate, duration, and extent of left ventricular relaxation in open-chest pigs?
Regional ischemia impairs active left ventricular relaxation and increases its sensitivity to volume and stretch, ultimately reducing the atrioventricular pressure gradient and filling.
Solomon et al. (1999) studied Regional ischemia. Regional ischemia vs. Normal perfusion was evaluated on Active component of relaxation, rate, duration, and extent of relaxation. Regional ischemia impaired active relaxation and increased the sensitivity of the relaxation rate to volume during left ventricular filling in open-chest pigs.
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