Key result
Left coronary artery occlusion for 30 minutes significantly increased the mean opening angle in rat hearts compared to sham-operated controls (51 vs 29 degrees; P<0.05).
Why the study?
Does acute myocardial ischemia alter residual stress and strain in the left ventricle of rat hearts?
Population
Rat hearts
Comparison
30 minutes of left coronary artery occlusion vs Sham-operated controls
Design
Preclinical
Follow-up
30 minutes
Authors
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Acute ischemia alters rat LV residual strain; leaves open translation to human myocardium or clinical relevance.
Does acute myocardial ischemia alter residual stress and strain in the left ventricle of rat hearts?
Absolute Event Rate: 51% vs 29%
p-value: p=< 0.05
Acute myocardial ischemia significantly alters residual strain in the left ventricle, likely related to changes in collagen fiber structure, myocyte structure, or metabolic state rather than simple overstretch.
Summerour et al. (1998) studied Acute myocardial infarction (n=23). Left coronary artery occlusion vs. Sham operation was evaluated on Mean opening angle (p=< 0.05). Left coronary artery occlusion for 30 minutes significantly increased the mean opening angle in rat hearts compared to sham-operated controls (51 vs 29 degrees; P<0.05).
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