Key result
In rats, large myocardial infarction resulted in significantly greater subendocardial collagen deposition in non-infarcted myocardium compared to sham, driven by reduced coronary driving pressure.
Population
Rat model of myocardial infarction, n=21 (3 groups of 7 rats each)
Comparison
Coronary artery ligature inducing small MI or… vs Sham surgery
Design
Preclinical
Follow-up
4 weeks
Authors
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Reduced coronary driving pressure may promote remote fibrosis post-MI; leaves open translation to human remodeling or therapeutic targets.
In a rat model of myocardial infarction, early reduction in coronary driving pressure independently predicts subsequent subendocardial fibrosis in remote, non-infarcted myocardium.
Frimm et al. (2003) studied Acute myocardial infarction (n=21). Coronary artery ligature (MI induction) vs. Sham surgery was evaluated on Subendocardial collagen volume fraction (CVF). In rats, large myocardial infarction resulted in significantly greater subendocardial collagen deposition in non-infarcted myocardium compared to sham, driven by reduced coronary driving pressure.
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