Key result
Left ventricular balloon inflation to higher maximum pressures increased LV volume up to 350% of unloaded volume, indicating myocardial preconditioning is better explained by strain softening.
p-value: p=<0.05
The preconditioning behavior of the myocardium is better explained by strain softening (damage to elastic components) rather than viscoelasticity.
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Strain softening may explain myocardial preconditioning in animal models; leaves open translation to human ventricular mechanics.
Emery et al. (1997) studied Left ventricular stiffness. Left ventricular balloon inflation to a new higher maximum pressure vs. Previous pressure history / Quasi-linear viscoelastic model was evaluated on Increases at 10 mmHg in LV volume (p=<0.05). Left ventricular balloon inflation to higher maximum pressures increased LV volume up to 350% of unloaded volume, indicating myocardial preconditioning is better explained by strain softening.
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