Key result
Mitral valve surgery in patients with end-stage congestive heart failure significantly improved left ventricular ejection fraction by a mean difference of 0.0748 compared to preoperative baseline.
Why the study?
Does mitral valve repair improve symptoms and cardiac function in patients with Mitral Regurgitation and advanced Congestive Heart Failure?
Observational (n=37)
Yes
Does mitral valve repair improve symptoms and cardiac function in patients with Mitral Regurgitation and advanced Congestive Heart Failure?
Mean Difference: 0.0748 (95% CI 0.0249–0.1247)
Absolute Event Rate: 0.36% vs 0.28%
p-value: p=0.0047
Mitral valve repair can be performed safely in patients with advanced heart failure and mitral regurgitation, leading to significant improvements in symptoms and ejection fraction.
May support mitral valve surgery for LVEF gains in end-stage heart failure; hypothesis-generating and should not change practice without RCTs.
Objective: The utility of mitral valve repair in patients with Mitral Regurgitation (MR) and advanced CHF remains controversial. Methods: 37 patients with MR and Left Ventricular Ejection Fraction (LVEF) 25% as well as patients with LVIDd Results: Operative mortality was 0% for the group. There were significant reductions in NYHA Class (p = 0.0004), mitral regurgitation (p 25%. There were no significant differences in cardiac outcome changes between patients with LVIDd 25%, and between patients with LVIDd Conclusions: MV repair in patients with low LVEF and MR can be performed safely, with significant improvement in LVEF and symptom profile. No survival difference were noted between those patients with severely depressed LVEF or those with elevated ventricular dimensions (LVIDd) when compared to those with less severe but still significant cardiac impairment. Consideration should be given to these patients as an option prior to transplantation.
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Nelson et al. (2012) conducted an observational in End-stage congestive heart failure with severe left ventricular dysfunction and mitral regurgitation (n=37). Mitral valve surgery (repair or replacement) vs. Pre-operative baseline was evaluated on Change in Left Ventricular Ejection Fraction (LVEF) (MD 0.0748, 95% CI 0.0249-0.1247, p=0.0047). Mitral valve surgery in patients with end-stage congestive heart failure significantly improved left ventricular ejection fraction by a mean difference of 0.0748 compared to preoperative baseline.
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