Key result
A narrowed lumen of distal afferent arterioles at 7 weeks in spontaneously hypertensive rats was associated with a 16% increase in mean blood pressure at 23 weeks.
Why the study?
Does a narrowed renal afferent arteriole at 7 weeks contribute to the later development of hypertension in spontaneously hypertensive rats?
Does a narrowed renal afferent arteriole at 7 weeks contribute to the later development of hypertension in spontaneously hypertensive rats?
A narrowed lumen of distal afferent arterioles early in life contributes to the later development of increased blood pressure in spontaneously hypertensive rats.
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Early afferent arteriole narrowing may precede hypertension in this model; leaves open relevance to human disease.
Nørrelund et al. (1994) studied Hypertension (n=37). Narrowed renal afferent arteriole (bottom lumen diameter quartile) vs. Top lumen diameter quartile was evaluated on Mean blood pressure at 23 weeks. A narrowed lumen of distal afferent arterioles at 7 weeks in spontaneously hypertensive rats was associated with a 16% increase in mean blood pressure at 23 weeks.
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